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a spermatogenesis study used 5 mg/kg/day for 30 days

Blood pressure-specific Increased oxidative stress can interfere with the production and availability of nitric oxide, a potent vasodilator

Hepatology 71 , 522538 (2020)

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The deletion of ATF4, an upstream factor of ChaC1, in embryonic fibroblasts, results in a ferric oxide-dependent death phenotype, emphasizing the role of ATF4 as a downstream molecule of the eIF2/ATF4 pathway (117)